品牌 | SOLARBIO/索萊寶 | 貨號 | K000346P |
---|---|---|---|
規(guī)格 | 50ul/100ul | 供貨周期 | 現(xiàn)貨 |
主要用途 | WB | 應用領(lǐng)域 | 醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)業(yè) |
Anti-MICA Polyclonal Antibody
英文名稱 | Anti-MICA Polyclonal Antibody |
---|---|
宿主 | Rabbit |
別名 | MIC-A;PERB11.1 |
應用 | WB |
稀釋比例 | WB 1:500-2000. |
交叉反應 | Human Mouse Rat |
蛋白分子量 | 43kDa |
Gene ID | 100507436 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
儲存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
純化方法 | Affinity purification |
亞型 | IgG |
免疫原 | Recombinant protein of human MICA |
性狀 | 液體 |
Public Immunogen Range | Recombinant protein of human MICA |
Subcellular Locations | Cell membrane Cytoplasm Single-pass type I membrane protein |
Swiss Prot | Q29983 |
克隆類型 | Polyclonal Antibody |
背景資料 | This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. |
多克隆抗體
抗原通常是由多個抗原決定簇組成的,由一種抗原決定簇刺激機體,由一個B淋巴細胞接受該抗原所產(chǎn)生的抗體稱之為單克隆抗體(Monclone antibody)。由多種抗原決定簇刺激機體,相應地就產(chǎn)生各種各樣的單克隆抗體,這些單克隆抗體混雜在一起就是多克隆抗體(Polyclonal antibody),機體內(nèi)所產(chǎn)生的抗體就是多克隆抗體。
由于多克隆抗體通常包含抗某一抗原的不同表位的抗體,所以,在深固定的樣本中也會很好地發(fā)揮效應,在石蠟包埋組織切片的染色中,多克隆抗體常選用。根據(jù)實驗的不同需要,多多克隆抗體應用于相應抗原的標記。此外,在農(nóng)業(yè)生產(chǎn)中,多克隆抗體被用于農(nóng)藥殘留現(xiàn)場監(jiān)測;在臨床應用中,多克隆抗體主要用于病原物的檢測、疾病的診斷及治療,如作為蛋白類免疫抑制劑用于移植反應和自身免疫病的治療。
索萊寶公司創(chuàng)立于2004年是一家擁有大批專業(yè)研發(fā)人員,專注于生物產(chǎn)品不斷完善和創(chuàng)新的公司。我們產(chǎn)品覆蓋面廣,品質(zhì)可靠。在優(yōu)化試劑產(chǎn)品線的同時,經(jīng)過多年研發(fā)經(jīng)驗的積累,也推出了新的抗體產(chǎn)品線。初期,大批科研人員精心設(shè)計,齊力設(shè)計出好的抗體產(chǎn)品;后期,質(zhì)檢工作者嚴格的質(zhì)量把控為我們保駕護航。終,在我們的共同努力之下,帶您見證索萊寶公司的又一奇跡。