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  • Anti-APP Polyclonal Antibody
產(chǎn)品名稱:

Anti-APP Polyclonal Antibody

產(chǎn)品品牌: SOLARBIO/索萊寶 價(jià)格:
廠商性質(zhì): 生產(chǎn)廠家 產(chǎn)品時(shí)間: 2022-08-15
Anti-APP Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:3000.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品概述

品牌SOLARBIO/索萊寶貨號K106430P
規(guī)格50ul/100ul供貨周期現(xiàn)貨
主要用途WB應(yīng)用領(lǐng)域醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)業(yè)

Anti-APP Polyclonal Antibody

英文名稱Anti-APP Polyclonal Antibody
宿主Rabbit
別名AAA;ABETA;ABPP;AD1;APPI;CTFgamma;CVAP;PN-II;PN2;preA4
應(yīng)用WB
稀釋比例WB 1:3000.
交叉反應(yīng)Human Mouse Rat
蛋白分子量120kDa
Gene ID351
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human APP
性狀液體
Public Immunogen RangeA synthetic peptide of human APP
Subcellular LocationsAmyloid Coated pit Membrane
Swiss ProtP05067
克隆類型Polyclonal Antibody
背景資料Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.

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